Non-synonymous insulin-dependent SLC30A8 so-called gluco-incretin signaling

Structural basis for the autoregulation of the zinc transporter YiiP
3H90 tunable transport activity in response to cytoplasmic metal fluctuations with antibody fragment
PDB Structure 3H90
SLC30A8, permit cellular efflux of zinc locus: 8q24.11: [§§]. ZNT8 is associated with the causation of noninsulin-dependent diabetes mellitus (NIDDM) by impaired proinsulin conversion, and included a nonsynonymous polymorphism in insulin-producing beta cells development or function of IDE, KIF11 and HHEX. CDKAL1 and CDKN2A/B on risk of T2DM were correlated with impaired pancreatic beta cell function, the Caucasian risk alleles for T2DM were associated with reduced insulin secretion in normoglycemic Pima Indians after admixture adjustments. SLC30A8 is a major autoantigen in type 1 diabetes and a known association with the TCF7L2 gene associated with impaired the so-called glucoincretin signaling, studies of the role of HK1 (hexokinase) in hemoglobin glycation, glucose metabolism, and diabetes.
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