Pol I-specific factor SL1


SL1 (Transcription initiation factor SL1/TIF-IB subunit C, RNA polymerase I-specific (species-specific)TBP-associated factor 110 kDa mediated TAF(I)110, SL1) is required for RNA polymerase I to synthesize ribosomal RNA of all 3 TAF1 proteins (TAF1A stromelysin-1: [§§], TAF1B: [§§] and TAF1C: [§§]) mutually exclusive binding to TBP excludeing TFIID binding selectivity factor of the RNA polymerase II locus: 1q42, 2p25 and 16q24 termed sulfolipid-1 (TAF1C-SL1). c-Myc and p53 binds to and associates with the Pol I-specific factor SL1 immature dimeric viral RNA palindrome one of the five most frequently mutated TAF(I)68 associated with PCNXL2 and a critical mechanistic link Runx2 complex containing RNA Pol I transcription factors UBF1 and SL1 that affects the rDNA promoter, PCAF acetylates TAF(I)68. The viral human rRNA promoter contains two factor upstream cis-control sequences, the core and upstream control element (UCE), SL1 and SL2 are not functionally equivalent.

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