Hepcidin antimicrobial peptideHepcidin antimicrobial peptide (HAMP) locus: 19q13 [§§], is a 25aa-amino-acid antimicrobial peptide systemic iron homeostasis depends on by a furin-dependent process, that disrupt the cell membranes of cellular pathogens. HAMP is most active against gram-positive bacteria also certain yeast and gram-negative species formed by the defensins as a subfamily of antimicrobially active peptides of animals and plants. TMPRSS6 as an essential component of a pathway that detects iron deficiency by controlling HAMP absorption and its upstream, USF2 gene. SLC40A1/ferroportin destroyed by interaction with the (HAMP) peptide, SLC40A1 is the only known transporter that facilitates iron egress.
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