IREBP Aconitase iron responsive elements

Aconitases are iron-sulfur proteins they catalyze conversion of upstream citrate to isocitrate (EC 4.2.1.3) , and functions as a cytoplasmic (IRE) iron responsive elements-binding protein (IREBP) interacts with the IREs expression of ferritin 5-prime mRNA and in the 3-prime, H-subunits and L-subunits (TfR) transferrin receptor or activation of IRP1-aconitase and IRP2 can independently function, responsive to uptake and storage of iron by the liver. Aconitase locus: 9p22-p13: [§§] is a bifunctional protein with mutually exclusive functions as an iron responsive element (IREBP/IRP)-binding protein, are isozymes present in the cytosol and mitochondria. IRP protein (wingless-type MMTV integration site family… Homo sapiens) is capable of forming two RNA-protein complexes regulated through the assembly/disassembly with three cysteine residues cytosolic isoforms of three major mammalian iron-sulfur cluster (ISC) pattern of expression involved in binding to ferritin, a [4Fe-4S / Fe-S]-cluster IRE RNA.
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