Ceruloplasmin mechanisms controlling the expression of proteins long known–

Like transferrin (TF), ceruloplasmin [CP] locus: 3q23-q24: [§§] (Cp, ferro-O2-oxidoreductase, EC, is a plasma metalloprotein link between copper and iron metabolism in mammals, ferroxidase found in vertebrate ferritin heavy chain [FTH1] regulate the oxidation of Fe(II) to Fe(III) necessary for iron egress from intestinal enterocytes into the circulation iron regulatory proteins (IRP)-1 and -2, and hepcidin for mutations might modulate the CP iron burden down-regulation, and up-regulation of Tfrc [transferrin receptor]-1 and 2. Ceruloplasmin is the major multicopper ferroxidase in blood. Iron overload associated with hereditary forms of hemochromatosis, 6p21.3, 20p12. Failure to incorporate multicopper ferroxidase 3q23-q24, is termed apoceruloplasmin.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: