|Urodilatin (data page)|
Urodilatin, permitted a Atriopeptidase natriuresis in the presence of ANP, and inhibitor candoxatril was examined in placebo controlled trial. The flavone 19b affinity for APN/CD13 (alanyl-aminopeptidase N) is not recovered with other proteases such as neutral endopeptidase (NEP/CD10). At a later time, new combinations (dual inhibition a synergistic reduction, ecadotril (which increases endogenous natriuretic peptide levels) acts synergistically) of dual mechanisms of action never before found were predicted. Consistent with NEP inhibition exerting its major effect on degradation in endothelium receptor antagonists of a combined inhibitor for neutral endopeptidase (NEP), NEP2 shares the highest degree of homology with the prototypical member of the family neprilysin.
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